This presentation explains the author’s collaborative work carried out with anthropologists from the Federal University of Amazonas and members of the Tucano and Tariano communities, which took place in Cachoeira de Laureté of the Uaupés and Papuri rivers on the Colombian-Brazilian border. The author reflects on the struggles of Indigenous peoples to achieve legal protection of this sacred place that is threatened by the proliferation of settlers, the construction of the northern perimeter highway, logging companies and so on. The talk highlights that the sacred character of the territory depends on a genuine ontological recognition, vital to understand the subjectivity and agency of this territory, which involves a complex and transdisciplinary vision of ecological thought.